Pradaxa - First New Oral Medication To Stop Blood Clotting In Over 50 Years Launched In Ireland Today Part 2

Pradaxa*  does  not  require  coagulation  monitoring**(7,8),  which  funds patients  do  not  need  to  have  even blood check to examine coagulation pursuit. Â  Pradaxa*  also  does  not  interact  with  food  and  have a run downhill potential  for  interactions  with  drugs  metabolised  by  cytochrome P450 enzymes.(9) Pradaxa*  works  by  target and inhibit thrombin, the principal and switch enzyme implicated within the foundation of blood set.(10,11) The  granting  of the licence in leg of Pradaxa* via the European Medicines Agency (EMEA)  follow the submission of efficacy and sanctuary rumour in February 2007 from  the  phase  III  RE-NOVATE  and RE-MODEL study.(12,13) Â  Oral, once respectively afternoon supervision of both 150 mg and 220 mg Pradaxa* be demonstrated to be  as  effective  and  well  tolerate by means of injectable enoxaparin (40 mg) in preventing  VTE  and  all  cause  mortality subsequent pure hip substitute surgery  and  total  knees replacement surgery in the RE-NOVATE and RE- MODEL trial, respectively.(12,13) With  all  anticoagulant  agents it be extensive to optimise the go together of efficacy  and  safety. Â  In  addition  to the critically important bleeding profile,  hepatic  and  cardiac  safety  requests to be considered, as okay as tolerability.  In both the RE-NOVATE and RE-MODEL trials, the rate of recurrence and severity  of  major  bleeding  (including  those  occurring at the surgical site), observed beside Pradaxa* was comparable to enoxaparin.

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